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The maximum safe dosage in a healthy person with a good (and unloaded) liver is 4 grams a day. If not treated quickly, a single 10 gram dose (or multiple doses adding up to 10g within 24 hrs, or 6g a day over 48 hours) is likely to result in liver toxicity, followed by death in a coma 3 to 5 days later.

The "standard percocet", meaning the Percocet version most commonly prescribed is known as a 5/325, which means 5 mg oxycodone plus 325 mg APAP. There are other combinations of each component, but none have less than 325 mg APAP.

APAP is responsible for more ER admissions for overdose than any other drug in the US, the UK, Australia, New Zealand, and other countries. In the US and in the UK, it is also the most common cause of acute liver failure.



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